SenTiva®

Smart Technology. Customizable Therapy. Based on Proven Results.

SenTiva® VNS Therapy device
SenTiva® and Next-Generation Programming System

SenTiva® and Next-Generation Programming System

SenTiva is an implantable and programmable pulse generator for treatment of refractory epilepsy. It provides responsive stimulation to rapid increases in heart rate that may be associated with seizures, allows day-night programming, scheduled programming and logging of low heart rate and prone position events.

New features for treatment customization and patient management
Wireless connectivity between programmer and wand
Intuitive workflow and programming interface
SenTiva™ detects and responds to rapid increases in heart rate that may be associated with a seizure

SenTiva™ and SenTivaDUO™ detect and respond to rapid increases in heart rate, which may be associated with a seizure1

In clinical trials, over 60% of seizures treated ended during automatic stimulation.

The closer the stimulation to seizure onset, the shorter the seizure duration2

VNS Therapy controls seizures in 3 ways

Normal Mode - Preventative

Normal Mode

Helps Prevent seizures

Stimulation is delivered at regular intervals all day, every day, to help prevent seizures1

Responsive* AutoStim Mode

AutoStim Mode

Responds to rapid increases in heart rate*

An extra dose of therapy is automatically delivered at the sign of a rapid increase in heart rate, which may be associated with seizures1,3,4

*Only available in models 106, 1000, and 1000-D

On-Demand Magnet Mode

Magnet Mode

Delivers On-Demand Treatment

Stimulation is manually delivered by swiping the included VNS Therapy™  magnet over the generator to help stop or shorten a seizure once it starts1

Responsive VNS Therapy* may provide additional seizure reduction

VNS Therapy™ with AutoStim can provide improvements in seizures control

mean follow-up 13 months 

p<0.001 N = 51

59% reported ≥ 50% reduction in seizures (N-30)

41% reported ≥ 80% reduction in seizures (N-21)

 

*Only available in models 106, 1000, and 1000-D

Customized control for when your patients need it

Customized control for when your patients need it

Day/Night Programming

  • Tailor programming for specific periods of the day
  • Select which parameters will change, what time the change will occur, and the duration of the change
  • Create two independent sets of therapy parameters at different times during a 24-hour period
Safely titrate patients automatically without office visits

Safely titrate patients automatically without the need for office visits

Scheduled Programming

  • Program a titration schedule in one office visit
  • Titration changes will be applied while the patient lives their life
  • Simply titrate to therapeutic range as fast as is tolerated
Treating seizures just got easier with SenTiva
Treating seizures just got easier

Confidently deliver VNS Therapy® with one touch

Guided Programming

  • Safe and easy pathway towards achieving targeted therapy levels
  • Follow an FDA-approved protocol or create custom protocols for specific patient profiles
Quickly visualize patient trends with SenTiva

Quickly visualize patient trends

Events & Trends

  • Quickly view long-term data at follow-up visits
  • Easily assess events of interest such as acute therapy activations, prone position, and low heart rate

SenTiva™ Spec Sheet

Download

SenTiva™ Duo Spec Sheet

Download

 

Want to find out more about SenTiva® and how it can help improve your patient outcomes?

SenTiva Resources

VNS Therapy Safety Profile

The most common side effects of VNS Therapy include:

Hoarseness
Shortness of breath
Sore throat
Coughing

These side effects generally only occur during stimulation and usually decrease over time.

Infection is the most common side effect of the procedure.

You can find more safety information here.

References
1. VNS Therapy System™ Epilepsy Physician’s Manual (US), March 2023, LivaNova USA, Inc. Houston, TX. 2. Data on file, LivaNova, Inc., Houston, TX. 3. Fisher RS, Afra P, Macken M, et al. Neuromodulation. 2016;19:188-195. 4. Hirsch M, Altenmüller DM, Schulze-Bonhage A. Epilepsia. 2015;56(10):1639-1647. 5. Datta P, Galla KM , Sajja K, et al. Epilepsy Behav. 2020;111:107280.

 

Epilepsy (US)  – The VNS Therapy™ System is indicated for use as an adjunctive therapy in reducing the frequency of seizures in patients 4 years of age and older with partial onset seizures that are refractory to antiepileptic medications. Incidence of adverse events following stimulation (>5%) were voice alteration, increased coughing, hoarseness, shortness of breath, sore throat and nausea. Infection is the most common adverse side effect of the surgical procedure. See important safety information at VNSTherapy.com/safety